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Updated: Dec 5, 2025

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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ヒト内生BAF複合体の構造モデルは,疾患メカニズムを伝達する

Nazar Mashtalir1, Hiroshi Suzuki2, Daniel P Farrell3

  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Cell
|October 14, 2020
PubMed
まとめ

研究者はヒトのBAF複合体の構造を明らかにし 核細胞に結合し クロマチンを再構成する方法を詳細に説明しました このBAF複合体 (BRG1/BRM関連因子) の構造的な洞察は,健康と病気におけるその役割を理解するのに役立ちます.

キーワード:
ATP依存クロマチンの改造BAF複合体癌についてクロスリンク マススペクトロメトリークリオ電子顕微鏡ホモロジーモデリング哺乳類のSWI/SNF複合体変異

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