成長差別化因子15は,COVID-19で入院した未選択患者の心血管および炎症バイオマーカーよりも優れた予後情報を提供します
Peder L Myhre1,2, Christian Prebensen3,2, Heidi Strand4
1Department of Cardiology (P.L.M., T.O.), Akershus University Hospital, Lørenskog, Norway.
Circulation
|October 15, 2020
まとめ
成長差別化因子15 (GDF-15) は,COVID-19患者の予後マーカーとして有望である. GDF-15濃度の上昇は,重度のアウトカムと相関し,予後を予測する他のバイオマーカーを上回ります.
科学分野:
- 生物化学
- 免疫学
- クリティカル ケア 医療
背景:
- 成長差別化因子15 (GDF-15) は,セプシスおよび心血管疾患 (CVD) の予後マーカーとして知られています.
- 2019年新型コロナウイルス病 (COVID-19) に関するGDF-15の予後的意義は,この研究の前に未決定のままでした.
研究 の 目的:
- COVID-19の入院患者におけるGDF-15の予後値の調査.
- COVID-19のアウトカムを予測する際に,GDF-15のパフォーマンスを確立された心血管および炎症バイオマーカーと比較する.
主な方法:
- SARS-CoV-2感染が確認された入院患者123人を対象に,前向きな観察研究が行われました.
- GDF-15濃度分析のために,ベースライン,第3日,第9日のバイオバンクサンプルを採取した.
- 主なエンドポイントは集中治療室に入院または入院中の死亡であり,GDF-15レベルは既知のバイオマーカーと比較された.
主要な成果:
- 79%の患者でGDF- 15濃度の上昇が観察され,SARS- CoV- 2ウイルス性血症および低酸素症 (P<0. 001) と関連した.
- 主要エンドポイントに達した患者は,AUC0. 78のGDF-15濃度 (中位4225 pg/ mL対2187 pg/ mL,P<0. 001) が有意に高かった.
- GDF-15は,インタールイキン-6,C反応性タンパク質,プロカルシトニン,フェリチン,D- ダイマー,心臓のトロポニンT,NT- プロBNPよりも優れた予後値を示した.
結論:
- GDF-15は,ほとんどの入院COVID-19患者で上昇しており,ウイルス性,低酸素性および有害な結果と相関しています.
- GDF-15は,既存の心血管および炎症バイオマーカーに優れ,インクリメンタルな予後情報を提供します.
- この研究では,GDF-15が重篤なCOVID-19アウトカムに対する強力な予後指標であると特定しました.
関連する概念動画
Role of Hematopoietic Growth Factors
2.7K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
2.7K
Regulation of Hematopoietic Stem Cells
3.7K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.7K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
395
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
395
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
631
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
631


