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関連する概念動画

The Nucleus01:25

The Nucleus

6.9K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
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The Nucleus01:32

The Nucleus

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The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
99.2K
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

5.1K
The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
5.1K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

24.4K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
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Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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関連する実験動画

Updated: Dec 5, 2025

Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers
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Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers

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細胞のダイナミックな行動を制御するために,細胞核は形状の変化を測定します.

Valeria Venturini1,2, Fabio Pezzano2, Frederic Català Castro1

  • 1ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels, Spain.

Science (New York, N.Y.)
|October 16, 2020
PubMed
まとめ
この要約は機械生成です。

細胞は核を物理的な指標として 形状の変化や 機械的なストレスを感知します この細胞のプロイオセプションは 細胞の行動を周囲の微小環境に適応させ 移動と収縮を制御します

さらに関連する動画

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
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Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

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関連する実験動画

Last Updated: Dec 5, 2025

Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers
09:56

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Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
16:27

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

Published on: September 14, 2011

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Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology
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Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology

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科学分野:

  • 細胞生物学
  • 機械生物学
  • 発達生物学

背景:

  • 細胞の微小環境は組織の発達とホメオスタシスを決定的に影響する.
  • 細胞が形状や 機械的なストレスのような 物理的なシグナルを感知し 反応する方法を理解することは 極めて重要です

研究 の 目的:

  • 組織内の機械的ストレス下で単細胞が幾何学的な形状情報を解読する方法を調査する.
  • 空間感知と適応の基礎となる細胞メカニズムを特定する.

主な方法:

  • ゼブラフィッシュのモデルシステムを使いました
  • 機械的なセンサーとしての核の役割を調査した.
  • 内核膜の動態とカルシウム依存の経路を分析した.

主要な成果:

  • 細胞の形状の変化を測定する 弾性変形計として機能します
  • 内核膜は,核の伸縮時に展開され,物理的な形状情報を提供します.
  • このプロセスは,アクトミオシン収縮性と細胞移動の可塑性を制御するカルシウム依存の経路を活性化します.

結論:

  • 核は細胞の自己受容の 重要な構成要素として機能します
  • 細胞は核を通して形状の変化を感知することで 微小環境に適応します
  • このメカニズムは 組織ホメオスタシスの維持と発達に不可欠です