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Updated: Dec 5, 2025

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time
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Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time

Published on: May 30, 2021

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モノメリックおよびアグレゲートされたα-シヌクレインによる非正規のDNA構造のコンフォルメーションダイナミクスの再構築

Jim-Marcel Knop1, Sanjib K Mukherjee1, Rosario Oliva1

  • 1Physical Chemistry I - Biophysical Chemistry, Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn Street 4a, 44227 Dortmund, Germany.

Journal of the American Chemical Society
|October 19, 2020
PubMed
まとめ

パーキンソン病のタンパク質アルファ-シヌクレイン (α-syn) は,G四重複体やiモチーフのようなDNA構造と相互作用する. この相互作用は遺伝子調節に影響し,集積されたα-synはG-四重複体を不安定化し,i-モチーフを安定させる.

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