TGF-βは2型がんに対する免疫を抑制する
Ming Liu1, Fengshen Kuo2, Kristelle J Capistrano1
1Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nature
|October 22, 2020
まとめ
2型免疫は通常 組織修復のために作られ がんと闘うことができます CD4+ T細胞におけるTGFBR2の減少は,この反応を誘発し,血管再構成と低酸素による腫瘍の成長を止めます.
科学分野:
- 免疫学
- 腫瘍学
- 組織修復
背景:
- 免疫系は病原体の破壊のためにタイプ1の免疫,組織修復のためにタイプ2の免疫を使用します.
- 免疫による癌細胞破壊は理解されているが,免疫媒介による癌細胞封じ込めはそれほど明確ではない.
研究 の 目的:
- 2型免疫が免疫媒介による癌細胞抑制に利用できるかどうかを調査する.
- CD4+ T細胞における成長因子β受容体2 (TGFBR2) の変容ががんの進行における役割を調査する.
主な方法:
- ガンモデルにおけるCD4+T細胞におけるTGFBR2の減少
- 免疫反応の分析 組織治癒 血管再構築
- 癌細胞の低酸素と生存率の評価
主要な成果:
- CD4+ T細胞ではTGFBR2が減ったが,CD8+ T細胞では癌の進行が止まった.
- この停止は 組織の治癒と血管の改造によって引き起こされ 癌細胞の低酸素化につながりました
- 保護反応は,Tヘルパー1のサイトカインインターフェロン-γ (IFN-γ) ではなく,Tヘルパー2のサイトカインインタールキン- 4 (IL- 4) に依存した.
結論:
- 2型免疫は癌に対する 組織レベルの防御機構として機能します
- TGFBR2をCD4+T細胞に標的にすると,がんを制御するための宿主指向の組織治癒反応が誘発される.
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