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Updated: Dec 4, 2025

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
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イブルーチニブ媒介の心房動は,C端部Srcキナーゼの阻害による

Ling Xiao1, Joe-Elie Salem2,3,4, Sebastian Clauss1,5,6

  • 1Cardiovascular Research Center (L.X., S.C., A.H., A.B., J.T., M.N., P.T.E., D.J.M.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Circulation
|October 23, 2020
PubMed
まとめ

イブルーチニブは,標的外効果であるC端のSrcキナーゼ (CSK) を阻害することで,心房細動 (AF) を引き起こします. この発見は このB細胞がん薬の 重要な副作用を説明します

キーワード:
BTKタンパク質,ヒトCSKチロシンタンパク質キナーゼ心房細動電気生理学イブルチニブタンパク質キナーゼ阻害剤

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