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Updated: Dec 3, 2025

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

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エピジェネティック・リーダー BRD4 (ブロモドメインを含むタンパク質4) 核エンコードされたミトコンドリアトランスクリプトームを制御し,心臓機能を調節する

Soo Young Kim1, Xin Zhang2, Gabriele G Schiattarella1

  • 1Division of Cardiology, Department of Internal Medicine (S.Y.K., G.G.S., F.A., K.M.F., N.J., P.A.S., H.I.M., X.L., L.I.S., S.L., T.G.G., J.A.H.), University of Texas Southwestern, Dallas.

Circulation
|October 28, 2020
PubMed
まとめ

ブロモドメインとBETタンパク質 BRD4は正常な心臓機能を維持するために不可欠です. 心筋細胞におけるBRD4の喪失は,拡張心筋病を引き起こし,ミトコンドリアのエネルギー生成を妨害し,心臓の健康におけるその重要な役割を強調する.

キーワード:
ヒトのBRD4タンパク質電子輸送エピジェネティクス心不全ミトコンドリアトランスクリプション,遺伝子

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