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関連する概念動画

Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

2.0K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
2.0K
Overview of Somatic Sensory Pathways01:29

Overview of Somatic Sensory Pathways

7.7K
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
7.7K
Somatosensation01:33

Somatosensation

42.5K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
42.5K
Spinal Cord: Information Processing01:10

Spinal Cord: Information Processing

2.6K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
2.6K
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

3.5K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
3.5K
Sympathetic Pathways: Sympathetic Chain Ganglia01:20

Sympathetic Pathways: Sympathetic Chain Ganglia

4.8K
The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...
4.8K

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関連する実験動画

Updated: Dec 3, 2025

Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans
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Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans

Published on: March 15, 2019

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感情的触覚と痛みの並行して上昇する脊髄経路

Seungwon Choi1, Junichi Hachisuka2,3,4, Matthew A Brett1

  • 1Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

Nature
|October 29, 2020
PubMed
まとめ

TACR1とGPR83の発現によって識別される2つの異なる脊髄投影ニューロン集団は,痛みと触覚信号のための並行経路を形成する. これらの経路は 感覚処理と 感情的行動における 異なる役割を明らかにします

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Recording Network Activity in Spinal Nociceptive Circuits Using Microelectrode Arrays
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Last Updated: Dec 3, 2025

Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans
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科学分野:

  • 神経科学
  • 感覚生物学
  • 痛みに関する研究

背景:

  • 脊髄から脳へ 痛み,体温,触覚の信号を伝達します
  • 痛みの仕組みを理解することは 効果的な痛みの治療法の開発に不可欠です
  • この経路にあるプロジェクションニューロンは 重要な治療目標です

研究 の 目的:

  • 組織的な論理を明らかにする.
  • 異なるニューロンの集団と 感覚処理におけるその役割を特定する.
  • これらの経路が触覚と痛みの感情的な側面に与える影響を調査する.

主な方法:

  • TACR1とGPR83を発現するプロジェクションニューロン集団の特定
  • スピノパラブラキアル (SPB) ニューロンの投影を横のパラブラキアル核に追跡する.
  • SPBニューロンのアクソン端末の光遺伝的刺激
  • 刺激に対するSPBニューロンの電気生理学的記録

主要な成果:

  • TACR1とGPR83を表現する2つの並列上昇回路モジュールが特定されました.
  • これらのモジュールは,熱,触覚,有害な皮膚信号を伝達します.
  • GPR83を発現するSPBニューロンは,機械的刺激に敏感であり,強度依存のバレンスを示す.
  • 刺激を受けた際には明確な亜核内置と行動反応が観察された.

結論:

  • 前側経路は,TACR1とGPR83の発現に基づいて,異なるSPBニューロンサブディビジョンで構成されています.
  • これらの部分には 独特の解剖学的,生理学的,機能的な性質があります
  • この発見は 感情的な触覚と痛みの感覚の 神経的基礎に光を当てました