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Updated: Dec 3, 2025

Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications
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Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications

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分解性C2対称型サイクロオクテンは,分子プローブの迅速かつ完全なバイオオートゴーナル分解を可能にします

Martin Wilkovitsch1, Maximilian Haider1, Barbara Sohr1

  • 1Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9, 1060 Vienna, Austria.

Journal of the American Chemical Society
|October 29, 2020
PubMed
まとめ

研究者らは,迅速かつ完全な分子ON/OFF制御のための新しいバイオオートホーゴナルリンクナー (C2TCO) を開発した. この画期的な発見により 生物系における高速で高精度な分子不活性化が可能になり バイオオートゴーナル化学の応用が進んでいます

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Cycloaddition Reactions: Overview01:16

Cycloaddition Reactions: Overview

Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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The molecular ions of cycloalkenes undergo fragmentation via a retro-Diels–Alder reaction.
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Thermal cycloadditions are reactions where the source of activation energy needed to initiate the reaction is provided in the form of heat. A typical example of a thermally-allowed cycloaddition is the Diels–Alder reaction, which is a [4 + 2] cycloaddition. In contrast, a [2 + 2] cycloaddition is thermally forbidden.
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