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Updated: Dec 3, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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M. 結核は血液形成幹細胞を再プログラムし,骨髄形成を制限し,訓練された免疫力を低下させる

Nargis Khan1, Jeffrey Downey1, Joaquin Sanz2

  • 1Meakins-Christie Laboratories, Department of Medicine, Department of Microbiology and Immunology, Department of Pathology, McGill University, Montreal, QC, Canada; McGill International TB Centre, McGill University Health Centre, Montreal, QC, Canada.

Cell
|October 30, 2020
PubMed
まとめ

Mycobacterium tuberculosis (Mtb) 感染症は,インターフェロン-I (IFN-I) 応答を通じて,血球形成性幹細胞 (HSC) を再プログラムし,訓練された免疫を損なう. この免疫回避戦略は,鉄代謝と骨髄における骨髄細胞の発達を妨げます.

キーワード:
BCG についてミコバクテリア 結核造血幹細胞鉄の代謝マクロファージモノサイト骨髄形成ネクロプトーシス訓練された免疫タイプI IFN

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