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Updated: Jul 28, 2026

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タンパク質電荷の工学による静電効果の予測

M J Sternberg1, F R Hayes, A J Russell

  • 1Department of Crystallography, Birkbeck College, London, UK.

Nature
|November 5, 1987
PubMed
まとめ

タンパク質の静電効果を予測することは,タンパク質設計の鍵です. 計算モデルにより,pKaがサブティリシンのシフトを正確に予測し,触媒活性を理解し,タンパク質工学の取り組みを導くのに役立ちました.

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