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Updated: Dec 2, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

Published on: June 21, 2017

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内部アルケンの間のアミンN-H結合の触媒的非対称添加

Yumeng Xi1,2, Senjie Ma1,2, John F Hartwig3,4

  • 1Department of Chemistry, University of California, Berkeley, CA, USA.

Nature
|November 3, 2020
PubMed
まとめ

この研究は,活性化されていない内部アルケンのエナチオセレクティブ水素酸化のための新しいイリジウム触媒を導入し,貴重なキラルアミンを生成します. 単純な原料から複雑な分子を 効率的に合成することができるのです

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The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
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The double bond in a simple, unconjugated alkene is a region of high electron density that can act as a weak base or a nucleophile. The filled π orbital (HOMO) of the double bond can interact with the empty LUMO of an electrophile. A bonding interaction occurs when the electrophile attacks between the two carbons; the electrophile then accepts a pair of electrons from the π bond and undergoes addition across the double bond, yielding a single product.
Addition and elimination...
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