関連する実験動画

Updated: Dec 2, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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GPCRイソフォームの組み合わせ表現は,シグナル伝達と薬物反応に影響する

Maria Marti-Solano1, Stephanie E Crilly2, Duccio Malinverni3,4

  • 1MRC Laboratory of Molecular Biology, Cambridge, UK. mmarti@mrc-lmb.cam.ac.uk.

Nature
|November 5, 2020
PubMed
まとめ

Gタンパク質結合受容体 (GPCRs) は,ユニークなシグナル特性を有する多様な機能的同位体を生成する. これらのアイソフォームの組織間での結合表現は,異なるシグナル状態を生み出し,薬物反応に影響を与え,新しい治療目標を提供します.

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