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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

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Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
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Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Factors Affecting Illness01:18

Factors Affecting Illness

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When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
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マルチオミクスは,軽度から中等度のCOVID-19の間の急性疾患状態のシフトを解決します.

Yapeng Su1, Daniel Chen1, Dan Yuan2

  • 1Institute for Systems Biology, Seattle, WA 98109, USA.

Cell
|November 10, 2020
PubMed
まとめ
この要約は機械生成です。

研究者は,139人のCOVID-19患者の臨床データ,免疫細胞,およびプラズママルチオミクスを分析した. 中程度の疾患は 重要な代謝と免疫の変化を示し

キーワード:
CITE-seq についてコロナウイルス免疫反応感染症メタボロミクスマルチオミクスプロテオミクス単細胞RNA-seqシングルセル TCR-seq単細胞分泌体

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Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
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Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

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Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
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Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
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Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
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科学分野:

  • 免疫学
  • メタボロミクス
  • COVID-19 研究

背景:

  • COVID-19は,疾患の重度の幅広いスペクトルを提示しています.
  • COVID-19の早期のシステミックな変化を理解することは,効果的な治療に不可欠です.

研究 の 目的:

  • COVID-19患者の統合された臨床,免疫,代謝プロフィールを,疾患の重症度を超えて調査する.
  • 病気の進行の重要な移行点と生物学的要因を特定する.

主な方法:

  • 139人のCOVID-19患者の臨床データ,免疫細胞フェノタイプ,およびプラズママルチオミックの統合分析.
  • 診断後最初の1週間で 血の採取を繰り返します
  • 単一の応答軸に 12万以上の免疫機能を縮小します.

主要な成果:

  • 軽度から中等度のCOVID-19の間には,プラズマの代謝産物と代謝プロセスの有意な変化が起こります.
  • 中等から重度の疾患で異常な免疫細胞の表型の出現と増幅.
  • "免疫応答軸"は,血の変化,血液の凝固,および疾患の重度の変化と相関する.

結論:

  • 適度なCOVID-19は,異なった代謝と免疫の変化を伴う重要な節目を表しています.
  • 特定された免疫応答軸は,SARS-CoV-2に対する宿主応答の統一された見方を提供します.
  • 治療の介入は,中程度の病気の段階で最も効果的です.