鳥の多様性の密集したサンプリングは,比較ゲノム学の力を高めます
Shaohong Feng1,2,3, Josefin Stiller4, Yuan Deng1,3,4
1China National GeneBank, BGI-Shenzhen, Shenzhen, China.
Nature
|November 12, 2020
まとめ
この研究は363の鳥のゲノムを分析し 密度の高い鳥のゲノム資源を生み出しました このリソースは,鳥類の進化,ゲノム多様性についての理解を向上させ,保全の取り組みを支援します.
科学分野:
- ゲノミクス
- 進化生物学
- バイオ情報学
背景:
- ゲノム全体の配列決定は 生物多様性に関する知識を広めています
- 系統遺伝学における稀少な分類サンプル採取は,不正確な推論につながり,ゲノム多様性を逃してしまう.
研究 の 目的:
- 鳥類の遺伝学と分子多様性の 濃厚な表現を作り出すこと
- 鳥の系統のオーソログの領域とゲノム新奇性を特定する.
- 進化と保全の研究のための貴重なゲノム資源を提供すること.
主な方法:
- 鳥1万ゲノム (B10K) プロジェクトから267の新しいゲノムを含む363の鳥ゲノムの分析.
- 参照のない全ゲノム配列パイプラインを使用して,正規の領域を識別します.
- 異なる鳥類のゲノムで単一塩基対の解像度で選択をマッピングする.
主要な成果:
- 鳥類の遺伝子多様性や分子多様性の 顕著な増加
- 以前よりも多くの正統領域と新しいゲノム特徴の特定.
- 保存された塩基の割合を2倍にし,非コーディングDNAにおける 弱い選択の広範なパターンを明らかにした.
結論:
- 比較研究におけるゲノム多様性の増加は,共有され,系統特有の変異の発見を高めます.
- 密集した鳥のゲノムデータセットは 進化の過程に関する新しい視点を提供します
- このゲノム資源は 種の保全に役立つでしょう
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