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Updated: Nov 30, 2025

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
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栄養はmTORC1-USP20-HMGCR軸経由でコレステロール生物合成を誘導する

Xiao-Yi Lu1, Xiong-Jie Shi1, Ao Hu1

  • 1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, the Institute for Advanced Studies, Wuhan University, Wuhan, China.

Nature
|November 12, 2020
PubMed
まとめ

デウビキチラーゼUSP20は,mTORC1によって調節される,食事後にコレステロール合成酵素HMGCRを安定させる. USP20を阻害すると,体重増加が減り,代謝の健康が改善され,新たな治療目標が提供されます.

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