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Updated: Nov 30, 2025

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
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Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry

Published on: November 29, 2013

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Adenosine Deaminase,TIM Barrel Hydrolase内の水素-デウテリウム交換は,触媒の熱活性化のためのネットワークを特定する

Shuaihua Gao, Emily J Thompson, Samuel L Barrow

  • 1David R. Cheriton School of Computer Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada.

Journal of the American Chemical Society
|November 12, 2020
PubMed
まとめ

タンパク質の柔軟性は,水素-デウテリウム交換質量スペクトロメトリ (HDX-MS) によって測定され,酵素触媒に関連しています. この研究は,ネズミのアデノシンデアミナーゼの変異がタンパク質のダイナミクスにどのように影響し,反応障壁を最適化するかを明らかにしています.

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