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Updated: Nov 30, 2025

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
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ZSWIM8ユビキチンリガゼは,ターゲット指向のマイクロRNAの分解を媒介する

Charlie Y Shi1,2,3, Elena R Kingston1,2,3, Benjamin Kleaveland4

  • 1Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Science (New York, N.Y.)
|November 13, 2020
PubMed
まとめ

ターゲット指向のmiRNA分解 (TDMD) は,ZSWIM8 E3ユビキチンリガスを必要とし,miRNAを分解に曝します. このメカニズムは多くの動物でマイクロRNAのレベルを形作ります

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