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関連する概念動画

Antigen Presenting Cells01:22

Antigen Presenting Cells

2.5K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
2.5K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.2K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.2K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

80.6K
Overview
80.6K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

7.5K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
7.5K
Tumor Immunotherapy01:27

Tumor Immunotherapy

955
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
955
T Cell Types and Functions01:24

T Cell Types and Functions

1.8K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.8K

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関連する実験動画

Updated: Nov 30, 2025

Artificial Antigen Presenting Cell aAPC Mediated Activation and Expansion of Natural Killer T Cells
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Artificial Antigen Presenting Cell aAPC Mediated Activation and Expansion of Natural Killer T Cells

Published on: December 29, 2012

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スナップショット: APC/T細胞免疫チェックポイント

Scott H Shrager1, Christina Kiel1

  • 1Systems Biology Ireland and UCD Charles Institute of Dermatology, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.

Cell
|November 13, 2020
PubMed
まとめ

免疫チェックポイントは 自己耐性や免疫反応を制御します これらのチェックポイントを活用することで 自己免疫疾患や癌を T細胞の活性化によって 治療できると見込まれています

科学分野:

  • 免疫学
  • 細胞生物学
  • 癌 研究

背景:

  • 免疫チェックポイントは自己耐性を維持し,免疫反応を制御するために不可欠です.
  • 免疫チェックポイントの調節不全は 自己免疫疾患や癌に 関わっている.
  • 免疫チェックポイントをターゲットにすることで 治療戦略が成功しています

研究 の 目的:

  • 免疫チェックポイントの相互作用を例示します
  • 抗原を提示する細胞 (APC) 媒介のT細胞調節に焦点を当てること.
  • これらのインタラクションの視覚的な概要 (SnapShot) を提供します.

主な方法:

  • 免疫チェックポイントに関する既存の文献のレビューと統合.
  • 抗原を提示する細胞 (APC) に関する相互作用に焦点を当てます.
  • T細胞変調経路の視覚表現

主要な成果:

  • 既知の免疫チェックポイントの相互作用の詳細な図解.
  • T細胞の反応を調節するAPCの役割を強調する.
  • T細胞の活性化と抑制における重要な制御点の特定

さらに関連する動画

Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells
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Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells

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Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation
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Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation

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関連する実験動画

Last Updated: Nov 30, 2025

Artificial Antigen Presenting Cell aAPC Mediated Activation and Expansion of Natural Killer T Cells
13:18

Artificial Antigen Presenting Cell aAPC Mediated Activation and Expansion of Natural Killer T Cells

Published on: December 29, 2012

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Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells
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Killer Artificial Antigen Presenting Cells KaAPC for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Published on: August 11, 2014

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Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation
10:16

Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation

Published on: October 12, 2018

8.3K

結論:

  • 免疫チェックポイントは 免疫反応の重要な調節器です
  • APC媒介のT細胞調節は治療介入の重要な分野である.
  • これらの相互作用を理解することは 癌や自己免疫疾患の 新規治療法の開発に不可欠です