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Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Clot Retraction and Fibrinolysis01:16

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After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

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The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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このページは機械翻訳されています。他のページは英語で表示される場合があります。View in English
  1. ホーム
  3. 研究分野
  5. 生物医学と臨床科学
  7. 心血管医学と血液学
  9. 心臓病 (心血管疾患を含む)
  11. Covid-19に関連した非閉塞性フィブリン微小血栓

COVID-19に関連した非閉塞性フィブリン微小血栓

Melanie C Bois1, Nicholas A Boire1, Andrew J Layman1

  • 1Department of Laboratory Medicine and Pathology (M.C.B., N.A.B., A.J.L., M.-C.A., M.P.A., A.C.R., C.E.H., R.A.Q., R.M., B.R.K., P.T.L., J.J.M.), Mayo Clinic, Rochester, MN.

Circulation
|November 16, 2020

関連する実験動画

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease
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Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease

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Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
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Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

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Author Spotlight: Developing a Translational Model for Atrial Fibrillation Research Across Species
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Author Spotlight: Developing a Translational Model for Atrial Fibrillation Research Across Species

Published on: November 21, 2023

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PubMed で要約を見る

まとめ
この要約は機械生成です。

この研究では,SARS-CoV-2による直接的な心臓感染症は発見されなかったが,COVID-19患者における一般的な心筋線維微血栓は明らかになった. 筋膜炎は一部の症例に存在し,心臓のアミロイドーシスは重度のCOVID-19のアウトカムを悪化させる可能性があります.

科学分野:

  • 心臓病科
  • ウイルス学
  • 病理学について

背景:

  • 深刻な急性呼吸器症候群の新型コロナウイルス2型 (SARS-CoV-2型) は,頻繁な心臓合併症による世界的な健康上の脅威であるCOVID-19を引き起こす.
  • COVID-19に関連する心臓疾患の正確なメカニズムはほとんど不明です.
  • 死亡後の心臓の評価は,SARS-CoV-2感染の病理を理解するために重要である.

研究 の 目的:

  • COVID-19患者における心筋病理スペクトルの詳細を明らかにする.
  • COVID-19における心臓の発見を他のウイルス性疾患と比較する.
  • 心臓におけるアンジオテンシン変換酵素2 (ACE2) の発現を調査し,治癒した感染症例における心臓の発見を記述する.

主な方法:

  • COVID-19 (n=15),インフルエンザ (n=6),および対照 (n=6) 症例の死後の心臓評価.
  • 生体病理学的分析,ACE2の免疫組織化学,超構造的検査,ウイルス検出のためのRT-PCR.
  • 異なる疾患グループと臨床状態 (活性 vs 治癒した感染) における結果の比較

主要な成果:

  • 非特異的なフィブリンマイクロトロンビは,活発なCOVID-19症例において一般的であった (P=0.006).
キーワード:
コロナウイルスSARS-CoV-2について解剖する心臓

関連する実験動画

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease
12:15

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease

Published on: February 8, 2022

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Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

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Author Spotlight: Developing a Translational Model for Atrial Fibrillation Research Across Species
08:52

Author Spotlight: Developing a Translational Model for Atrial Fibrillation Research Across Species

Published on: November 21, 2023

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  • 焦点性心筋炎は,通常限られた範囲で,活発な (33.3%) およびクリアされたCOVID-19症例で観察されました.
  • 低動脈ACE2内皮発現はCOVID-19症例 (P=0. 004) で観察されたが,心筋ACE2発現は異なっていなかった.
  • 心臓アミロイドーシスはCOVID-19患者の26.7%で確認された.

    • 結論:

    • SARS-CoV-2 の直接的な心筋感染症は,決定的に特定されなかった.
    • 心筋線維微血栓はCOVID-19で頻繁に見られるが,普遍的に不血性損傷と関連しているわけではない.
    • COVID-19患者のサブセットで発現する心筋炎は,治癒した感染では表情が変動する.
    • 心臓のアミロイドーシスは,重症なCOVID-19疾患の追加的な危険因子である可能性があります.
    病理学について