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目に見える光による二重フォトレドックス/ニッケル触媒によるアルケンのエナチオセレクティブ三成分炭酸化の一般的方法

  • 0State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Center for Advanced Low-Dimension Materials, Donghua University, Shanghai 201620, China.
Journal of the American Chemical Society +

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2020年11月19日

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2020年11月19日

PubMedで要約を見る

まとめ

この要約は機械生成です。

新しい可視光法により,アルケンのエナチオセレクティブカルボアリレーションが可能になり,貴重なキラル分子が生成されます. この効率的なプロトコルは フルビプロフェンの類型のような複雑な化合物を 高精度で合成します

科学分野

  • 有機化学
  • カタリシス
  • 合成方法論

背景

  • 有機合成において,C−C結合形成のための効率的なエナンチオセレクティブの方法の開発は極めて重要です.
  • 三要素反応は原子経済と合成コンバージェンスを提供します

研究 の 目的

  • アルケンのエナチオセレクティブの3つの成分カルボアリレーションのための可視光促進プロトコルを開発する.
  • 多様な機能群を持つβ-アルキル-α-アリレート化合物に アクセスする.

主な方法

  • 可視光光レドックス触媒とニッケル触媒を組み合わせた
  • アルケンのアルキルトリフローロボラートとアリルブロミドとの反応.
  • 実験的・計算的メカニズム研究

主要な成果

  • アルケンのエナチオセレクティブ3成分カルボアリレーションを達成した.
  • エナチオ濃縮β-アルキル-α-アリレートカルボニル,フォスフォナート,および硫黄素を大量に生成し,エナチオ選択性がある.
  • フルビプロフェンの類似体とピラグリアチン鉛化合物の合成による合成効用が実証された.

結論

  • 開発されたプロトコルは,価値あるキラルビルディングブロックへの容易で異なるアクセスを提供します.
  • 反応の選択性についての洞察を 提供している.
  • この方法は複雑な有機分子を合成する大きな可能性を秘めている.

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