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Updated: Nov 29, 2025

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pH依存型コンフォメーションスイッチ制御 髄膜炎 ClpP プロテアゼ機能

Zev A Ripstein1,2, Siavash Vahidi1,2,3,4, John L Rubinstein1,2,5

  • 1Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

Journal of the American Chemical Society
|November 24, 2020
PubMed
まとめ

pHに依存するスイッチは,ClpPタンパク質の形状を制御し,活発な拡張型と不活性な圧縮型の間でシフトします. この形状の変化は,Neisseria meningitidisのようなバクテリアのClpPプロテアゼ機能の調節に不可欠です.

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