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Updated: Nov 28, 2025

PCR Mutagenesis, Cloning, Expression, Fast Protein Purification Protocols and Crystallization of the Wild Type and Mutant Forms of Tryptophan Synthase
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PCR Mutagenesis, Cloning, Expression, Fast Protein Purification Protocols and Crystallization of the Wild Type and Mutant Forms of Tryptophan Synthase

Published on: September 26, 2020

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フェニララニンのサイクロヘキシララニンへの変異は,Aβから派生したβ-ヘアピンによる三角型トリマー形成を促進する

Sepehr Haerianardakani1, Adam G Kreutzer1, Patrick J Salveson1

  • 1Department of Chemistry, University of California, Irvine, Irvine, California 92697, United States.

Journal of the American Chemical Society
|November 25, 2020
PubMed
まとめ

研究者は,アミロイドβ (Aβ) 派生ペプチドにPhe20からサイクロヘキシララニンへの変異を設計した. この変異はAβオリゴーマーを安定させ,その構造と細胞毒性を明らかにし,アルツハイマー病の病原性についての洞察を提供します.

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