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スプライシングファクターYBX1は,JAK2変異性腫瘍の持続を媒介する

Ashok Kumar Jayavelu1, Tina M Schnöder2,3, Florian Perner2

  • 1Max Planck Institute of Biochemistry, Munich, Germany.

Nature
|November 26, 2020
PubMed
まとめ

変異したJAK2が 骨髄増殖性腫瘍を誘発する JAK2の標的であるYBX1を JAK2阻害剤と共に無活性化すると,JAK2変異細胞のアポトーシスと寛解が誘発されます.

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