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関連する概念動画

Solving Problems in Physics02:32

Solving Problems in Physics

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Problem-solving is the ability to apply general physical principles to specific situations, usually expressed by equations. It is an essential skill in physics, and can also be useful for applying physics in everyday life as well. Analytical skills and problem-solving abilities can be applied to new situations, compared to a list of facts, which can never be extensive enough to include every possible circumstance. To solve physics problems, a certain amount of creativity and insight is...
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The Scope of Physics01:17

The Scope of Physics

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Physics is concerned with the interactions of energy, matter, space, and time, in order to discover the underlying mechanisms that underpin all phenomena. The word "physics" comes from the Greek word "phúsis", which means nature. Physics seeks to comprehend the natural world around us at its most fundamental level. It emphasizes the use of quantitative laws to do this, which could be valuable in other fields that want to push the performance boundaries of present...
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Kinematic Equations: Problem Solving01:15

Kinematic Equations: Problem Solving

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When analyzing one-dimensional motion with constant acceleration, the problem-solving strategy involves identifying the known quantities and choosing the appropriate kinematic equations to solve for the unknowns. Either one or two kinematic equations are needed to solve for the unknowns, depending on the known and unknown quantities. Generally, the number of equations required is the same as the number of unknown quantities in the given example. Two-body pursuit problems always require two...
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Kinetic Energy for a Rigid Body01:13

Kinetic Energy for a Rigid Body

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Imagine a solid object involved in a general planar movement, with its center of mass pinpointed at a spot labeled G. The object's kinetic energy relative to an arbitrary point A can be quantified for each of its particles - the ith particle in this case. This measurement is achieved through the employment of the relative velocity definition. The position vector, known as rA, extends from point A to the mass element i.
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Newton's First Law: Introduction01:17

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Motion draws our attention. Motion itself can be beautiful, causing us to marvel at the forces needed to create spectacular sights, such as that of a dolphin jumping out of the water, the flight of a bird, or the orbit of a satellite. The study of motion is kinematics, but kinematics only describes the way objects move—their velocity and acceleration. Dynamics considers the forces that affect the motion of moving objects and systems. Newton's laws of motion are the foundation of...
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Kinetic Energy00:23

Kinetic Energy

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Kinetic energy is the ability of an object in motion to do work or enact change. It can take on many forms. For instance, water flowing down a waterfall has kinetic energy. In biological systems, particles of light travel and are absorbed by plants to create chemical energy. Animals consume the chemical energy and give off molecules that carry their scent through the air. They also generate kinetic energy when they run away from predators. Entire systems also possess kinetic energy, like the...
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Electron Cryotomography of Bacterial Cells
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タンパク質のストーリーテリング

Emiliano Brini1, Carlos Simmerling1,2, Ken Dill3,2,4

  • 1Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794, USA.

Science (New York, N.Y.)
|November 27, 2020
PubMed
まとめ
この要約は機械生成です。

計算型分子物理学 (CMP) は タンパク質の行動に関する理解に革命をもたらしています このアプローチは 詳細なタンパク質のダイナミクスを明らかにするために 物理学の原理を用いて 生物学的発見を進めています

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科学分野:

  • バイオ物理学
  • コンピュータ生物学
  • 構造生物学

背景:

  • タンパク質には 折り畳み,結合,機能など 複雑な生物学的な役割があります
  • タンパク質の構造は タンパク質の振る舞いを理解するために 伝統的に使用されています
  • タンパク質のダイナミクスを理解することは,生物学的プロセスや病気を理解するために不可欠です.

研究 の 目的:

  • タンパク質の振る舞いを解読する計算分子物理学 (CMP) の 成長する役割を強調する.
  • タンパク質の構造動態に関する詳細な洞察をCMPが提供する方法を説明する.
  • CMPの最近の進歩を紹介し,より大きな生物学的システムとより長い時間スケールの研究を可能にします.

主な方法:

  • タンパク質の振る舞いをモデル化するために 物理学の原理を活用します
  • 空間と時間の両方で構成集団を分析する.
  • タンパク質のダイナミクスをシミュレートするために 先進的な計算技術を使用します

主要な成果:

  • CMPは,タンパク質の折りたたみ,結合,および生物学的作用に関する詳細な情報を明らかにします.
  • 最近の進歩は,より長い時間スケールとより大きな分子システムの研究を可能にします.
  • ブラインドテストは,タンパク質の行動を理解する上で,CMPの予測力を検証します.

結論:

  • タンパク質の"物語"を語るために 計算型分子物理学はますます重要になってきています
  • CMPは 伝統的な構造生物学を補完する 物理に基づいた強力なアプローチを提供します
  • CMPの継続的な進歩は 原子レベルでより深い生物学的な洞察を 解き放つことを約束しています