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Updated: Nov 28, 2025

A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors
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RNAポリメラーゼIIフォスファタゼであるインテグレーターPP2A複合体 (INTAC) の識別

Hai Zheng1,2, Yilun Qi1, Shibin Hu1

  • 1Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.

Science (New York, N.Y.)
|November 27, 2020
PubMed
まとめ

インテグレーター複合体は,タンパク質フォスファタゼ2A (PP2A- AC) を結合して,RNAポリメラーゼIIを脱酸化し,RNAトランスクリプトを分裂させ,転写を調節する新しい酵素INTACを形成する.

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