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動脈硬化性心血管疾患に対する抗血栓療法 冠動脈疾患および糖尿病患者のリスク軽減

Davide Capodanno1, Dominick J Angiolillo2

  • 1Division of Cardiology, A.O.U. Policlinico "G. Rodolico-San Marco," University of Catania, Italy (D.C.).

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|November 30, 2020
PubMed
まとめ
この要約は機械生成です。

糖尿病 (DM) の患者は血栓症のリスクが高く,心血管疾患が増加します. 冠動脈疾患 (CAD) のDM患者における強烈な抗血栓治療は,出血リスクを相殺して,臨床上の純利益をもたらします.

キーワード:
アスピリン冠動脈疾患糖尿病 糖尿病二重抗血小板療法ダブルパス阻害

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科学分野:

  • 心臓病科
  • 薬理学について
  • 糖尿病について

背景:

  • 糖尿病 (DM) の患者は,高反応性血小板,高凝固性,内皮機能不全により,高血栓症のリスクを示します.
  • この増加したリスクは,冠動脈疾患 (CAD) が認められた場合と認められていない場合の両方で,動脈硬化性心血管疾患 (ACE) の発生を誘発する.

研究 の 目的:

  • DMとCADの患者におけるACEの原発的および二次的予防のための現在のおよび新興の抗血栓戦略をレビューする.
  • この高リスク集団における強化された抗血栓治療の臨床的利益を評価する.

主な方法:

  • DMとCADの患者の抗血栓療法に関する既存の文献のレビュー.
  • 単一の抗血小板療法,二重抗血小板療法,二重経路阻害戦略の分析
  • DM患者の出血リスクに対する利益の検討

主要な成果:

  • 確立されたCADのないDM患者では,アスピリンの主要な予防効果はしばしば出血のリスクによって相殺されます.
  • 既定のCADのDM患者では,抗血小板剤による二次予防が不可欠です.
  • 二重経路阻害を含む強化された抗血栓治療は,高出血リスクを除外されたDM患者において,臨床的利益を示している.

結論:

  • DMとCADの患者は,出血のリスクが増加したにもかかわらず,強力な抗血栓療法から著しく恩恵を受けています.
  • 濃縮抗血栓療法による臨床効果を最大化するには,慎重に患者を選択することが重要です.
  • 進行中の研究は,CADのDM患者に対する抗血栓的アプローチを最適化することを目的としています.