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同性および異性のマウント行動の明確な下垂体制御
Tomomi Karigo1, Ann Kennedy1,2, Bin Yang1
1Division of Biology and Biological Engineering, TianQiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, CA, USA.
Nature
|December 3, 2020
まとめ
オスマウスは,超音波発声 (USV) によって差異化され,雌性 (生殖) と雄性 (攻撃性) の異なる神経経路を示している. この研究は 特定の下垂体ニューロン集団を使って 複雑な行動を解読します
科学分野:
- 神経科学
- 動物 の 行動
- 内分泌学
背景:
- 似たような動物の行動は 異なる意図を隠すことができます
- これらの意図を区別する 神経の基礎は 雄のマウスのマウスのように 明確ではありません
- 男性のマウスは 異なる文脈で 雌と雄の両方に対してマウスを示す.
研究 の 目的:
- オスマウスにおけるメス向けとオスの方向のマウントが,異なる神経基板によって媒介されているかどうかを調査する.
- これらの異なる行動に関与する特定の下垂体ニューロン集団を特定する.
- 神経活動パターンが 異なる行動の意図を 暗号化する仕組みを理解するためです
主な方法:
- エストロゲン受容体1 (ESR1) 陽性ニューロンの中央前視領域 (MPOA) と中腹下垂体 (VMHvl) の微視内視画像を用いた.
- 特定のニューロンのサブ集団 (MPOA ESR1VGATとVMHvl ESR1ニューロン) の光遺伝的刺激を用いる.
- マウント行動 (USV+ vs. USV-) を区別するために,超音波発声 (USVs) を分析した.
主要な成果:
- MPOAとVMHvlにおける神経活動の明確なパターンは,USV+ (女性向け,生殖性) とUSV- (男性向け,攻撃性) のマウントを区別した.
- MPOAニューロンの光遺伝的刺激はUSV+の増殖を促し,男性向け攻撃をUSVの増殖に変換した.
- VMHvlニューロンの刺激はUSVの増殖を促し,女性の尿で誘発されるUSVを阻害し,MPOA- VMHvlの相互抑制を示唆した.
結論:
- 男性の特定の生殖および攻撃的行動状態を因果的に誘発する異なる下垂体ニューロン集団 (MPOA ESR1VGATおよびVMHvl ESR1) を特定した.
- 繁殖状態と攻撃的な状態は,MPOAとVMHvlで異なる集団コードでコード化されています.
- 異なる意図を持つ類似した行動は 異なる下垂体ニューロン集団によって表現され 行動における神経の柔軟性を強調する.
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