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Updated: Nov 27, 2025

Simultaneous Quantification of Selected Kynurenines Analyzed by Liquid Chromatography-Mass Spectrometry in Medium Collected from Cancer Cell Cultures
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内皮細胞インドレアミン2,3-ダイオキシゲネーゼ1は,キヌレニンによる心筋梗塞後の心臓機能を変化させる

Nada Joe Melhem1, Mouna Chajadine1, Ingrid Gomez1

  • 1Université de Paris, Paris-Centre de Recherche Cardiovasculaire (PARCC), Institut National de la Santé et de la Recherche Médicale, France (N.-J.M., M.C., I.G., K.-Y.H., M.B., C.K., Y.S., M.R., L.L., M.L., J.V., Z.M., A.T., H.A.-O., J.-S.H., J.-S.S., S.T.).

Circulation
|December 4, 2020
PubMed
まとめ

インドレアミン2,3- 二酸化酵素1 (IDO) 抑制は,心筋梗塞 (MI) の後の心臓損傷を制限する. 内皮細胞のIDOを削除すると,心臓の機能が改善され,不良な再構成が減少し,IDOがMIの治療標的であることを示唆しています.

キーワード:
IDO (インディオ)アポトーシスキヌレニン心筋梗塞トリプトファン

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