関連する実験動画

Updated: Nov 27, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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劣化性キノームのマッピングは,劣化剤の開発を加速させるためのリソースを提供します

Katherine A Donovan1, Fleur M Ferguson1, Jonathan W Bushman1

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Cell
|December 4, 2020
PubMed
まとめ

標的型タンパク質分解 (TPD) はタンパク質を排除するために分子を使用しますが,発見は非効率です. この研究では,キナーゼ分解剤を特定し,キナーゼ分解のp97依存性を明らかにし,TPD戦略を改善しました.

キーワード:
E3リガゼIMiD についてプロタック劣化剤キナーゼターゲットを絞った劣化ユビキチンウビキチンプロテアソーム系

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