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Updated: Nov 27, 2025

Author Spotlight: Understanding Cytokine-Induced Cell Death in Intestinal Epithelial Cells Using Human Organoids
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Author Spotlight: Understanding Cytokine-Induced Cell Death in Intestinal Epithelial Cells Using Human Organoids

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TNF-α と IFN-γ の相乗効果は,SARS-CoV-2 感染およびサイトカインショック症候群における炎症性細胞死,組織損傷および死亡率を誘発する

Rajendra Karki1, Bhesh Raj Sharma1, Shraddha Tuladhar1

  • 1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Cell
|December 5, 2020
PubMed
まとめ

腫瘍死滅因子-α (TNF-α) とインターフェロン-ガンマ (IFN-γ) は,特定の細胞死,PANoptosisを誘発し,COVID-19モデルの重症な炎症と死亡率を引き起こします. この経路を阻害することで 致死性サイトカインショックと感染を防ぐことができます

キーワード:
コロナウイルスIFN-γパノプトーシスSARS-CoV-2についてTNF-αアポトーシスサイトカインストーム炎症ネクロプトーシスピロプトーシス

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