Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Bipolar Disorder01:30

Bipolar Disorder

420
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
420
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

434
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
434
Borderline Personality Disorder01:25

Borderline Personality Disorder

321
Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
321
Personality Disorders: Paranoid and Schizoid01:22

Personality Disorders: Paranoid and Schizoid

325
Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
325
Personality Disorders: Schizotypal and Histrionic01:20

Personality Disorders: Schizotypal and Histrionic

274
Schizotypal personality disorder and histrionic personality disorder are two distinct psychological conditions classified under personality disorders, each characterized by unique behavioral patterns and social difficulties. Both disorders significantly affect interpersonal relationships and emotional well-being, leading to social isolation and frustration.
Schizotypal Personality Disorder: Eccentric Behavior and Social Withdrawal
Schizotypal personality disorder is marked by odd or eccentric...
274
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

356
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
356

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Distinct cognitive changes in male patients with obstructive sleep apnoea without co-morbidities.

Frontiers in sleep·2024
Same author

Modafinil for Severe Fatigue in Inflammatory Bowel Disease: A Prospective Case Series.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2024
Same author

Ketamine cystitis following ketamine therapy for treatment-resistant depression - case report.

BMC psychiatry·2024
Same author

Trazodone in the Management of Major Depression Among Elderly Patients with Dementia: A Narrative Review and Clinical Insights.

Neuropsychiatric disease and treatment·2023
Same author

Limited clinical validity of univariate resting-state EEG markers for classifying seizure disorders.

Brain communications·2023
Same author

The effect of a low-calorie diet on depressive symptoms in individuals with overweight or obesity: a systematic review and meta-analysis of interventional studies.

Psychological medicine·2023

関連する実験動画

Updated: Nov 27, 2025

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

954

双極性障害

Roger S McIntyre1, Michael Berk2, Elisa Brietzke3

  • 1Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.

Lancet (London, England)
|December 6, 2020
PubMed
まとめ

双極性障害は慢性疾患で 寿命と機能に重大な影響を及ぼします 遺伝子は重要な役割を果たしますが 双極性障害の理解と治療には 環境要因や併発性も重要です

さらに関連する動画

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

10.0K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

2.9K

関連する実験動画

Last Updated: Nov 27, 2025

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

954
Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

10.0K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

2.9K

科学分野:

  • 精神医学と行動科学
  • 遺伝学とゲノミクス
  • 神経科学

背景:

  • 双極性障害 (BPI,BPII) は重症で慢性的な精神疾患で,心理社会的機能と平均寿命を短縮します.
  • 高い遺伝性 (70%) は,双極性障害を他の精神的および医学的状態と結びつけ,BPI (統合失調症) とBPII (重度うつ病) に際して明確な遺伝的関連性がある.
  • 病原性には神経膠質の可塑性,モノアミナージックシグナル伝達,炎症,細胞代謝,ミトコンドリア機能不全が含まれる.

研究 の 目的:

  • 主治医に双極性障害の診断,病原性,治療に関する概要を提供すること.
  • 流行病学,メカニズム,スクリーニング,および双極性障害の治療に関する現在の証拠を統合する.
  • 双極性障害の管理における併発症と心理社会的要因の重要性を強調する.

主な方法:

  • 双極性障害に関する既存の証拠のレビューと統合
  • 遺伝的関連,病原性経路,環境の影響の分析
  • 現在の薬理学的および心理学的治療戦略の評価

主要な成果:

  • 躁鬱症がBPIを定義しているにもかかわらず,うつ病エピソードは双極性障害の罹患率と死亡率に大きく寄与する.
  • リチウムは精神安定剤の黄金規格であり マニアには効くが 双極性抑うつには効かない
  • 双極性障害における抗うつ薬の使用は,強力な有効性証拠が欠如し,気分不安定化を引き起こす可能性があります. 効果的な治療へのアクセスは世界的に制限されています.

結論:

  • 双極性障害の効果的な治療には 医療や精神疾患の併発症に対処し 心理社会的治療を統合し 介護者を巻き込む必要があります
  • 主治医は双極性障害の検診,診断,治療において重要な役割を果たします.
  • 特に双極性うつ病の治療のアクセシビリティと有効性を改善するためにさらなる研究が必要です.