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リンパ節は,免疫調節能力を持つユニークな感覚神経細胞集団によって神経化されます
Siyi Huang1, Carly G K Ziegler2, John Austin1
1The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Immunology & HMS Center for Immune Imaging, Harvard Medical School, Boston, MA 02115, USA.
Cell
|December 17, 2020
まとめ
嗅覚受容体と呼ばれる神経細胞はリンパ節 (LN) を監視します これらのニューロンは炎症信号を検知し,LN細胞の遺伝子発現を変化させ,免疫反応に影響を与えます.
科学分野:
- 神経免疫学
- 感覚生物学
- リンパ系の研究
背景:
- 障壁組織における免疫反応は部分的に神経受容体によって制御される.
- ノシセプターの除去は,周辺部と排水リンパ節 (LNs) の局所的な免疫に影響を与えます.
- LN機能に対するノシセプターの正確なメカニズムと重要性はまだ不明です.
研究 の 目的:
- ノシセプターがリンパ節機能を調節するメカニズムを調査する.
- リンパ節免疫を調節する神経免疫回路を特定する
- リンパ節の状態と局所的な免疫反応を監視する感覚神経の役割を理解する.
主な方法:
- 高解像度画像と ウイルス追跡と 光遺伝学を使って 神経免疫相互作用を研究した
- リンパ節アトラスを作成し,細胞標的を特定するために単細胞トランスクリプトミクスを利用しました.
- リンパ節を神経化する感覚神経のサブセットのトランスクリプトミカルプロファイリングを行いました.
主要な成果:
- 異なる感覚神経のサブセットを特定した. 主にペプチダーギーノシセプター, リンパ節を神経化する.
- これらのニューロンが リンパ系による炎症信号に反応する回路を形成することを発見しました
- オプトジェネティック刺激により,リンパ節内皮,ストロマ細胞,および先天性白血球の急速な転写変化が誘発された.
結論:
- 感覚神経細胞のユニークな集団が 周辺リンパ節を活発に監視しています
- これらのノシセプターは,リンパ節居住細胞の遺伝子発現を局所的に調節する可能性があります.
- この感覚神経免疫回路はリンパ節内の局所的な免疫反応を調節する役割を果たします.
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