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Updated: Nov 25, 2025

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
06:19

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抗癌薬候補によるヒトモノカルボキシラートトランスポーター1の阻害

Nan Wang1, Xin Jiang2, Shuo Zhang1

  • 1State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Cell
|December 17, 2020
PubMed
まとめ

陽子結合モノカルボキシラートトランスポーター (MCT) は細胞代謝と癌の成長に不可欠です. この研究は,乳酸またはがん薬阻害剤に結合するMCT1の構造を明らかにし,輸送機構を明らかにし,薬の開発を支援します.

キーワード:
7ACC2 についてAZD3965BAY-8002についてバシジン/CD147MCT についてSLCトランスポーター交互アクセスクリオ・エム乳酸輸送モノカルボキシラートトランスポータープロトンカップリング

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