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Updated: Nov 25, 2025

Examination of Thymic Positive and Negative Selection by Flow Cytometry
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Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

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前T細胞受容体は,チモサイト β選択中にトポロジカルに自己リガンドをサンプリングする

Xiaolong Li1,2,3, Réka Mizsei1, Kemin Tan4

  • 1Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA, USA. jwang@crystal.harvard.edu ellis_reinherz@dfci.harvard.edu.

Science (New York, N.Y.)
|December 18, 2020
PubMed
まとめ

T細胞前受容体 (pre-TCR) は,アルファベータT細胞受容体 (TCR) の"垂直"結合とは異なる"水平"結合メカニズムを使用してペプチドをサンプリングします. このTCR前での相互作用は,後のTCRの選択とレパートリーの多様化を導く.

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