保存された細胞型集合を繰り返し複製することによって進化した小脳核
Justus M Kebschull1, Ethan B Richman1,2,3, Noam Ringach1
1Department of Biology, Stanford University, Stanford, CA 94305, USA.
Science (New York, N.Y.)
|December 18, 2020
まとめ
複合的な脳進化は 保存された細胞型の集合を 脳の核で複製することを含みます この過程で シンプルな回路が 複雑な脳領域に 進化する過程が説明されます
科学分野:
- 神経科学
- 進化生物学
- ゲノミクス
背景:
- 単純な回路から複雑な脳の進化は 神経科学の根本的な問題です
- 脳の領域の進化を促す 細胞と分子のメカニズムを理解することは 極めて重要です
研究 の 目的:
- 脳の領域の進化を,小脳核内の細胞タイプレベルで調査する.
- 種間の保存と分岐の細胞集団と 脳進化におけるその役割を特定する.
主な方法:
- 単核RNA配列解析はマウス,鶏,ヒトで行われました.
- STARmapの空間トランスクリプトーム解析と中枢神経系全体のプロジェクショントレーシングが利用された.
- 小脳核の細胞型組成と接続性の比較分析
主要な成果:
- 2つの領域特有の刺激性ニューロンクラスと3つの領域不変性抑制性ニューロンクラスを含む,保存された細胞タイプが小脳核で特定されました.
- この保存されたセットは,新しい領域を生成するために複製された原型小脳核を形成します.
- マウスの側頭前皮質に発射する特定の刺激性細胞クラスは,拡張した人間の側頭核に優勢である.
結論:
- 脳の領域の進化は 細胞型全体の複製と分岐によってモデル化できます
- 発見は小脳と機能的な組織の進化的拡大の洞察を提供します.
- この研究は,神経回路の進化を理解するための細胞型の解像度枠組みを提供します.
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