逆相液体クロマトグラフィのキラル分離のための非常に安定したZr(IV) 基の金属有機フレームワーク
Hong Jiang1, Kuiwei Yang2, Xiangxiang Zhao1
1School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China.
Journal of the American Chemical Society
|December 28, 2020
まとめ
非常に安定したジルコニウムベースの金属有機フレームワーク (MOF) は,逆相高性能液体染色体 (RP-HPLC) のための効率的なキラル静止相 (CSP) として導入されています. これらの新しいMOFは,アミノ酸や薬物を含む様々なラセマットを分離する際の優れた性能を示しています.
科学分野:
- 材料科学
- 分析化学
- 有機化学
背景:
- キラル分離は化学と薬理学において極めて重要であり,MOFのような多孔質物質はキラル静止相 (CSP) として研究されている.
- 主要な分離方式である逆相高性能液体クロマトグラフィー (RP-HPLC) のための効果的なCSPの開発は,依然として大きな課題です.
研究 の 目的:
- RP-HPLCのCSPとして高度に安定したジルコニウムベースのMOFの有効性を実証する.
- ステレオ選択的認識のための調整可能なチャネルサイズを持つ新しいキラルMOFを合成し,特徴づけること.
主な方法:
- 1,1'-ビフェニル-20-クラウン-6から派生したエナンチオプアテトラカルボキシラートリガンドを用いた3つのキラル多孔性Zr(IV) -MOFの合成
- MOFの構造,安定性 (水,酸,塩基耐性),およびチャネル特性の特徴
- 酸性水性エリューエント条件下での様々なレースマートの分離のためのMOFを詰め込んだHPLCコラムの評価.
- 分離選択性のメカニズムを解明するための密度関数理論 (DFT) の計算.
主要な成果:
- 同じトポロジーを有する3つのZr-MOFが,異なるチャネルサイズで合成され,高い安定性を示した.
- MOFチャネル内のキラル・クラウンエーテル分子は,ゲスト分子のステレオ選択的認識を可能にしました.
- これらのZr-MOFでパックされたHPLCコラムは,モデルレースマットを分離する際に高解像度,選択性,耐久性を達成しました.
- 分離性能は,RP-HPLCの既存の商用キラルカラムに匹敵し,または優れていた.
結論:
- 非常に安定したZrベースのMOFはRP-HPLCの有効で堅固なCSPです.
- キラル・クラウン・エーテルによって支配される,MOF内の閉じ込められたマイクロ環境は,分離選択性を支配する.
- これらの新しいMOFは,要求の高いクロマトグラフィのアプリケーションにおけるキラル解像度のための有望なプラットフォームを提供します.
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