急性 軟骨 炎: 原因,診断,治療
Olwen C Murphy1, Kevin Messacar2, Leslie Benson3
1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lancet (London, England)
|December 28, 2020
まとめ
急性軟骨髄炎 (AFM) は,エンテロウイルスによって引き起こされる,小児麻痺のような障害である. このレビューは,公衆衛生上の重大な問題であるAFMの診断,管理,およびリハビリテーションをガイドしています.
科学分野:
- 神経学
- 感染症
- 公衆衛生
背景:
- 急性軟骨髄炎 (AFM) は,主に子供に影響する重度の神経疾患です.
- 突然の筋肉の弱さで特徴付けられ,AFMは呼吸不全につながり,他の神経学的障害を模倣します.
- 2012年以降のアウトブレイクでは 原因はポリオ以外のエンテロウイルスで 世界的な健康問題となっています
研究 の 目的:
- 急性軟骨髄炎の疫学,臨床的特徴,アウトカムをレビューする.
- AFM患者の診断,管理,リハビリテーションのガイドラインを提供すること.
- AFMの理解と治療のための将来の研究方向を特定する.
主な方法:
- 急性軟骨髄炎に関する既存の文献のレビュー
- 診断のための臨床表現,神経画像,脳脊髄液の特徴の分析.
- 患者のアウトカムとリハビリテーションの必要性の検討
主要な成果:
- AFMは深い筋肉の弱さであり,しばしば残留障害を伴う.
- 診断には,臨床検査,画像検査,およびCSFの検査を組み合わせる必要があります.単一の検査は決定的ではありません.
- 患者は専門の長期リハビリテーションを必要とします.
結論:
- AFMは公衆衛生上の大きな課題であり,診断と管理の戦略を向上させる必要があります.
- 宿主と病原体の相互作用と標的治療に関するさらなる研究が不可欠です.
- 遺伝的,ウイルス性,免疫学的要因を理解することで 患者の長期的な成果が改善されます.
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