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関連する概念動画

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
7.8K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.6K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.6K
Stem Cell Niche01:26

Stem Cell Niche

5.8K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

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Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
2.7K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.4K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
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ノシセプティブ神経は,血液形成幹細胞の動員を調節する

Xin Gao1,2, Dachuan Zhang1,2, Chunliang Xu1,2

  • 1Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, USA.

Nature
|December 28, 2020
PubMed
まとめ

交感神経だけでなく,ノシセプティブ神経は,血液形成幹細胞 (HSC) の動員に不可欠です. これらの神経はカルシトニン遺伝子関連ペプチド (CGRP) を放出し,HSCを直接骨髄から離れさせる.

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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons
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Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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科学分野:

  • 血液学
  • 神経科学
  • 幹細胞生物学

背景:

  • 血液形成幹細胞 (HSC) は,骨髄の特殊なニッチに存在します.
  • 交感神経はHSCのニッチに影響しますが, nociceptiveニューロンの役割は不明です.

研究 の 目的:

  • 骨髄のニッチ内のHSCの動員と維持におけるノシセプティブニューロンの役割を調査する.

主な方法:

  • 痛感神経の活動に対する HSC の動員を調査した.
  • ノシセプター由来因子による HSC 脱出の分子メカニズムを分析した.
  • CGRPがHSCに及ぼす直接的な影響を調査した.

主要な成果:

  • ノシセプティブ神経は,交感神経と協働して,強制的なHSCの動員に不可欠です.
  • ノシセプターはCGRP分泌を通じてG-CSF誘発のHSCを駆動する.
  • CGRPは,RAMP1とCALCRLを通じてHSCに直接作用し,Gαs/アデニルサイクラゼ/cAMP経路経由で脱出を促進する.
  • カプサイシン摂取は,マウスのHSCの活性化を高めました.

結論:

  • ノシセプティブニューロンは HSCの動員に重要な役割を果たします
  • 痛感神経系をターゲットにすることで,治療目的のHSCの効果が向上する可能性があります.