関連する実験動画

Updated: Nov 23, 2025

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
11:33

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes

Published on: March 12, 2013

13.6K

KCNE1は,2つの異なるイオンチャネルスーパーファミリーの補助サブユニットです

Pablo Ávalos Prado1, Stephanie Häfner1, Yannick Comoglio1

  • 1Université Cote d'Azur, CNRS, INSERM, iBV, Nice, France; Laboratories of Excellence, Ion Channel Science and Therapeutics, Nice, France.

Cell
|December 29, 2020
PubMed
まとめ

以前,心臓のカリウムチャネルにおける役割で知られていたKCNE1補助サブユニットは,TMEM16A塩化物チャネルを調節します. この相互作用はTMEM16Aチャネル機能を変化させ,遺伝性疾患に関与する可能性があります.

キーワード:
ISK についてKCNE1MinK1 について補助サブユニットアノクタミンカリウムチャンネルタンパク質複合体隣接した状管細胞単一分子の光電圧依存イオンチャネル

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Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry11:32

Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry

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Recapitulation of an Ion Channel IV Curve Using Frequency Components10:14

Recapitulation of an Ion Channel IV Curve Using Frequency Components

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GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
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