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Updated: Nov 23, 2025

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
06:40

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms

Published on: January 25, 2018

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小分子薬によるγ-分泌酵素抑制と調節の構造的基礎

Guanghui Yang1, Rui Zhou2, Xuefei Guo2

  • 1Beijing Advanced Innovation Center for Structural Biology and Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China; State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.

Cell
|December 29, 2020
PubMed
まとめ

γ-分泌酵素阻害剤 (GSI) と調節剤 (GSM) に関する構造的な洞察は,アルツハイマー病と癌の経路をどのように標的としているかを明らかにする. これらのメカニズムを理解することは 次世代の治療法の開発の鍵です

キーワード:
クリオ・エム麻薬阻害剤モジュレーター構造γ-セクレターゼ

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