関連する実験動画

Updated: Nov 21, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

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マスター・レギュラー・ランドスケープは,癌の転写的アイデンティティを制御する

Evan O Paull1, Alvaro Aytes2, Sunny J Jones1

  • 1Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Cell
|January 12, 2021
PubMed
まとめ

この研究は,マスターレギュレータ (MRs) と呼ばれる重要なタンパク質を特定することによって,癌細胞の遺伝的変化が異なる腫瘍サブタイプを生成する方法を明らかにしています. これらのMRIは癌の説明に役立ちます.

キーワード:
癌の遺伝学癌システム生物学ゲノム改変統合型ゲノミクスマルチオミクスネットワーク分析パンガン分析トランスクリプション 規制

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