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食物抗原に対する局所免疫反応は,食事による腹痛を誘発する
Javier Aguilera-Lizarraga1, Morgane V Florens1, Maria Francesca Viola1
1Laboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium.
Nature
|January 14, 2021
まとめ
腹痛のような 食物に起因する胃腸症状は 免疫反応を引き起こす 細菌感染から生じることがあります この反応は神経を敏感にし,特定の食べ物を食べると痛みを引き起こします.
科学分野:
- 胃腸内科
- 免疫学
- 神経科学
背景:
- 食物に起因する胃腸症候群は 世界で20%まで発生し 生活の質や医療費に影響します
- これらの症状の背後にあるメカニズムは 理解されていない.
研究 の 目的:
- 食物に起因する腹痛の根本的なメカニズムを調べる
- 刺激性腸症候群 (IBS) および関連疾患の潜在的な治療標的を特定する.
主な方法:
- バクテリア感染後のマウスの食事による抗原に対する免疫反応の誘導.
- 内臓の痛みの信号伝達経路の評価
- IBS患者におけるマスト細胞活性化と局所組織反応の分析
主要な成果:
- バクテリア感染と毒素は,マウスの食事による抗原に対する腸特異IgE抗体の生成を誘発する.
- 後に抗原を摂取すると,ヒスタミンH1受容体媒介によるIgEおよびマスト細胞依存の内臓の痛みが生じます.
- 食物抗体はIBS患者で局所的な腫れとマスト細胞活性化を誘発した.
結論:
- IgE,マスト細胞,ヒスタミンが関与する周辺的メカニズムが,食物誘発の腹痛を媒介する.
- この発見はIBSやその他の腹痛の治療法に 新たな可能性を秘めています
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