新皮質シナプスの構造と機能
Simone Holler1, German Köstinger1, Kevan A C Martin1
1Institute of Neuroinformatics, University of Zurich and ETH Zurich, Zurich, Switzerland.
Nature
|January 14, 2021
まとめ
研究者はマウスの脳における シナプスの大きさと 伝送の強さを関連付けました この発見はニューロンの構造を 脳機能と結びつけ ニューロンのシナプスが 以前より複雑であることを示しています
科学分野:
- 神経科学
- シナプスの可塑性
- コネクトミックス
背景:
- 電子顕微鏡は 神経回路の詳細な再構築を可能にしました
- シナプス構造と機能の関係を理解することは 神経科学における重要な課題です
研究 の 目的:
- シナプスの大きさと生理学的伝達力の関係を調査する.
- 新皮質のシナプスにおける神経伝達物質の放出部位の数を決定する.
主な方法:
- 照明と高解像度の電子顕微鏡を組み合わせたスライス電気生理学
- ネズミの体感皮質のピラミッドニューロン間のシナプス接触を分析した.
主要な成果:
- シナプスの大きさと伝達力の間の線形的な関係が見られた.
- 量子解析では,シナプスあたり平均で少なくとも2. 7の神経伝達物質の放出部位が示された.
- 神経皮質のシナプスは多発性放出を示し,より複雑なことを示唆する.
結論:
- シナプスの大きさは シナプスの強さの信頼できる予測であり,構造的および機能的なコネクトミクスを橋渡しします.
- 神経皮質のシナプスは以前より複雑な計算単位である.
- 発見は,皮質のマイクロ回路内の計算能力の理解を拡大します.
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