麻痺したSARS-CoV-2特異性胎盤抗体移植
Caroline Atyeo1, Krista M Pullen2, Evan A Bordt3
1Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; PhD Program in Virology, Division of Medical Sciences, Harvard University, Boston, MA 02115, USA.
Cell
|January 21, 2021
まとめ
妊婦のSARS-CoV-2感染は,特に妊娠3ヶ月間では,乳児への抗体伝播を減少させます. この研究では,抗体グリコシル化と補償メカニズムが変化し,母体ワクチン開発の洞察を提供している.
科学分野:
- 免疫学
- 母親と胎児の医療
- ウイルス学
背景:
- 妊婦はSARS-CoV-2によるより重症な病気を経験する.
- 乳児の免疫伝染に対する母性SARS-CoV-2感染の影響は不明である.
- 母親の感染症は胎盤の抗体移転を危うくすることがありますが,そのメカニズムは不明です.
研究 の 目的:
- 胎盤経由のSARS-CoV-2 特定の抗体移転を調査する.
- 移植された抗体のFcプロフィールを特徴付ける.
- 妊娠中の抗体移転に影響を与えるメカニズムを理解する.
主な方法:
- 抗体プロファイルを分析するために,システム血清学が採用されました.
- インフルエンザ, pertussis,SARS-CoV-2に特有の抗体を研究した.
- 胎盤からの転移と抗体の機能的活性が評価された.
主要な成果:
- インフルエンザと pertussisに特異的な抗体は効率的に転送されます.
- SARS-CoV-2 特定の抗体移転は,特に第3 trimester 感染において,著しく減少しました.
- 転移の減少は抗体グリコシレーションの変化と関連しており,IgGと胎盤FCGR3Aの発現の増加によって部分的に補償された.
結論:
- 母親のSARS-CoV-2感染は新生児への抗体伝播を阻害する.
- 抗体グリコシル化と胎盤因子の変化が,移植効率に影響する.
- 発見は補償メカニズムを示唆し,母親のワクチン戦略を伝える.
さらに関連する動画
05:31Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
1.1K
09:57Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay
Published on: August 6, 2020
6.7K
関連する概念動画
01:15Transcytosis of IgG
3.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
3.7K
01:22Development of Immunocompetence
584
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
584