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ホストサクシネートは,細胞内感染時のサルモネラウイルス性の活性化信号である

Gili Rosenberg1, Dror Yehezkel1, Dotan Hoffman1

  • 1Department of Biological Regulation, Weizmann Institute of Science, 7610001 Rehovot, Israel.

Science (New York, N.Y.)
|January 22, 2021
PubMed
まとめ

細胞内サルモネラ菌はマクロファージのサクシネート蓄積を感知し,その抵抗性と毒性を高めます. このバクテリアの適応は 宿主と病原体の交信が 病原体の生存に繋がっていることを示しています

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Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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