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Updated: Jun 13, 2026

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
22:10

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

Published on: June 28, 2013

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プレチデプシンは,宿主タンパク質eEF1Aを標的にすることで,SARS-CoV-2に対する強力な臨床前有効性を持っています

Kris M White1,2, Romel Rosales3,2, Soner Yildiz3,2

  • 1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. kris.white@mssm.edu nevan.krogan@ucsf.edu adolfo.garcia-sastre@mssm.edu.

Science (New York, N.Y.)
|January 26, 2021
PubMed
まとめ

プリチデプシンは,SARS-CoV-2に対する強力な抗ウイルス活性を示し,レムデシビルをインビトロで大幅に上回る. ユカリオットトランスレーション延長因子1Aを標的としたこの薬は,マウスモデルにおけるウイルスの複製を効果的に減少させ,COVID-19治療の有望性を示した.

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