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Updated: Nov 19, 2025

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アヌプロイド症は,癌細胞をミトーシスチェックポイントの抑制に脆弱にする

Yael Cohen-Sharir1, James M McFarland2, Mai Abdusamad2

  • 1Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Nature
|January 28, 2021
PubMed
まとめ

アヌプロイドがん細胞は 独特の脆弱性を表しています スピンドル・アセンブリ・チェックポイント (SAC) をターゲットにすると,長期的な増殖欠陥が明らかになり,がん治療の潜在的な治療標的としてKIF18Aが特定されます.

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Nondisjunction01:21

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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
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