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合併シャトル反応と,可逆性バイシナルジヒロゲネーションのためのペアリング電解

  • 0Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, Zürich, Switzerland.
Science (New York, N.Y.) +

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2021年1月29日

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Electrophilic Addition to Alkynes: Hydrohalogenation 02:35

10.8K

Electrophilic addition of hydrogen halides, HX (X = Cl, Br or I) to alkenes forms alkyl halides as per Markovnikov's rule, where the hydrogen gets added to the less substituted carbon of the double bond. Hydrohalogenation of alkynes takes place in a similar manner, with the first addition of HX forming a vinyl halide and the second giving a geminal dihalide.

Addition of HCl to an Alkyne
Mechanism I – Vinylic carbocation Intermediate
The mechanism begins with a proton transfer from HCl to the...

Electrophilic 1,2- and 1,4-Addition of X<sub data-lazy-src=

3.1K

Electrophilic addition of halogens to alkenes proceeds via a cyclic halonium ion to form a 1,2-dihalide or a vicinal dihalide.

Conjugated dienes react with halogens in a similar manner. However, in addition to the 1,2-dihalide, they also form a 1,4-dihalide. The mechanism involves two steps.
First, a nucleophilic attack by one of the diene π bonds on the electrophilic center of the polarized halogen molecule forms a halonium ion intermediate. This is followed by a nucleophilic attack of the...

Preparation of Alkynes: Dehydrohalogenation 02:34

17.1K

Introduction
Alkynes can be prepared by dehydrohalogenation of vicinal or geminal dihalides in the presence of a strong base like sodium amide in liquid ammonia. The reaction proceeds with the loss of two equivalents of hydrogen halide (HX) via two successive E2 elimination reactions.

Reaction Mechanism – E2 pathway
Vicinal dihalides
In the first elimination step, the strong base abstracts the proton from the dihalide that is oriented anti to the leaving group. Since E2 reactions follow a...

Halogenation of Alkenes 02:46

17.5K

Halogenation is the addition of chlorine or bromine across the double bond in an alkene to yield a vicinal dihalide. The reaction occurs in the presence of inert and non-nucleophilic solvents, such as methylene chloride, chloroform, or carbon tetrachloride.
Consider the bromination of cyclopentene. Molecular bromine is polarized in the proximity of the π electrons of cyclopentene. An electrophilic bromine atom adds across the double bond, forming a cyclic bromonium ion intermediate.

A...

[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction 01:16

11.5K

The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.

From a molecular orbital perspective, the interacting lobes of the two π systems must be in phase to permit...

Regioselectivity of Electrophilic Additions to Alkenes: Markovnikov's Rule 02:17

15.5K

If a set of reactants can yield multiple constitutional isomers, but one of the isomers is obtained as the major product, the reaction is said to be regioselective. In such reactions, bond formation or breaking is favored at one reaction site over others.
The hydrohalogenation of an unsymmetrical alkene can yield two haloalkane products, depending on which vinylic carbon takes up the halogen. However, one product usually predominates, where hydrogen adds to the vinylic carbon bearing the...