中年期の女性における冠動脈カルシウムに関連した妊娠糖尿病と妊娠後のグルコース耐性: CARDIA研究
PubMedで要約を見る
まとめ
この要約は機械生成です。妊娠後の血糖値に関係なく,妊娠糖尿病 (GD) の歴のある女性は冠動脈結晶 (CAC) のリスクが2倍になります. GD の後の正常な血糖値を達成することは,この心血管疾患のリスクの上昇を軽減しません.
科学分野
- 心臓病科
- 内分泌学
- 公衆衛生
背景
- 妊娠糖尿病 (GD) は2型糖尿病と心血管疾患 (CVD) のリスクを高めます.
- GDの既往歴のある女性のCVDリスクに対するノルモグリセミアの影響は不明である.
- 冠動脈結晶 (CAC) は動脈硬化性CVDの初期症状である.
研究 の 目的
- 女性におけるCACによる妊娠後のGDとグルコース耐性の関連性を評価する.
- GDの歴史に関連したCVDリスクの増加を緩和するかどうかを判断する.
主な方法
- 若年成人における冠動脈リスクの発達 (CARDIA) 研究のデータ分析
- 妊娠前の糖尿病のない1133人の女性を対象に,シングルトン出産と25年以上の可用性グルコース耐性およびCAC測定を行った.
- GDの歴史と後のグルコース耐性状態に基づいて,CACの調整された危険比率を推定するための統計モデル化.
主要な成果
- GDの女性では,CACの罹患率は25%で,GDの女性では15%でした.
- すべてのグルコース耐性レベルにおいて,GDの病歴はCACの2倍以上のリスクと関連していました.
- GD歴のない女性では,グルコース耐性の悪化とともに,CACリスクの段階的な増加が観察されました.
結論
- 妊娠糖尿病の歴は冠動脈の結石化のリスクを大幅に高めます.
- GD の後にノルモグリセミアに達しても,動脈硬化性心血管疾患のリスクが増加することはありません.
- 後の血糖のコントロールに関係なく,GDの病歴はCVDの持続的リスクを伴います.
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